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Can I Eat Natto While Taking Blood-Thinning Medication?

Three types of blood thinning Patients who visit cardiovascular outpatient clinics for diseases such as myocardial infarction, cerebral infarction, and atrial fibrillation (arrhythmia that causes cardiogenic cerebral infarction) often take ``blood thinning drugs.'' These diseases are diseases in which blood clots clog in blood vessels, so drugs that prevent blood clots are needed...

About this translation This English version is provided for convenience. If any wording differs from the Japanese version, the Japanese version applies.

There are 3 types of blood smoothness

Patients visiting cardiovascular outpatient clinics for diseases such as myocardial infarction, cerebral infarction, and atrial fibrillation (arrhythmia that causes cardiogenic cerebral infarction) often take ``medications to thin the blood.'' These diseases involve blood clots clogging the blood vessels, so drugs that prevent blood from clumping are needed. It is not uncommon for patients to be taking more than one type of medicine, and I am often asked, ``Is it okay to take such blood-thinning medicines?'' There are three types of blood thinning medicine (note: this is just a simple explanation).

typecommon nameApplicable diseases
antiplatelet agentAspirin, clopidogrel, prasugrel, etc.After coronary artery stent placement, cerebral infarction
warfarinwarfarinatrial fibrillation, deep vein thrombosis
Direct oral anticoagulants (DOACs)Edoxaban, dabigatran, etc.atrial fibrillation, deep vein thrombosis
(Note) For convenience, this is a classification used when explaining to patients.

Warfarin is the reason I can't eat natto.

The reason I can't eat natto is because of the drug warfarin. Warfarin exerts its anticoagulant effect by inhibiting the production of vitamin K-dependent clotting factors in the liver. To put it more simply, it "interferes with vitamin K and prevents the production of substances that clot blood." Natto is rich in vitamin K, which makes warfarin less effective. Other green and yellow vegetables also contain vitamin K, but eating even a pack of natto can make warfarin ineffective for a long period of time, so people are advised to strictly limit their intake of natto.

Is it OK to eat natto other than warfarin?

Antiplatelet agents and direct oral anticoagulants do not interfere with vitamin K, so there is no particular problem. As a side note, warfarin is also affected by antibiotics, so if you are being prescribed antibiotics by someone other than your primary care physician, it is a good idea to tell them that you are taking warfarin.

Blood thinning medicine that you should not eat natto
warfarin It is.
Other antiplatelet agents and direct oral anticoagulants are not a problem.